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How long does it take for Betamethasone to work? A course of treatment for 7-14 days is often sufficient. If your symptoms have not improved after this time (or if they get worse), speak again with your doctor for further advice. Topical corticosteroids like betamethasone should not be used for long periods of time or on large areas of the body. Can I buy betamethasone over the counter? Official Answer. Topical corticosteroids are available over the counter (OTC) but of only mild potency e.g. hydrocortisone cream. Betamethasone cream is a potent corticosteroid so is restricted to prescription only to ensure that is used safely and appropriately.
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