Is exocrine pancreatic insufficiency fatal? This condition can lead to poor absorption of nutrients, weight loss, and a shortage of vitamins. Two of the main causes of exocrine pancreatic insufficiency (EPI) are cystic fibrosis and chronic pancreatitis. The pancreas is one of the organs that make up the gastrointestinal (GI) system. Do Digestive enzymes help pancreatitis? The pancreas secretes digestive enzymes into the small intestine through a tube called the pancreatic duct. These enzymes help digest fats, proteins, and carbohydrates in food. Chronic pancreatitis does not resolve itself and results in a slow destruction of the pancreas.
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